In silico study of the ageing effect upon aortic valves

A fluid–structure interaction (FSI) numerical model of the aortic valve was used to simulate and compare young physiological aged operating conditions. The effect normal ageing considered by introducing alterations typically associated with senility: namely mild stiffening tissues progressive dilation chamber. aim this study is provide a haemodynamic baseline which allows assess typical variations advancing age. Results were analysed in terms leaflets kinematics, flow dynamics, pressure performance parameters. indicates that changes occurring ageing, such as root dilation, can result substantial haemodynamics mechanical efficiency valve. In particular, tissue reduce over cardiac cycle. concomitant presence both phenomena lead some mitigation impairment. observed changes, be healthy need taken into consideration when evaluating real pathological contribution diseases patients.